NOVEL DRUG FORM OF CHLORIN E6

Chlorine 6 has been known to be attractive as photosensitizer (PS) for PDT for long. Its usefulness as a photosensitizing part of photoimmunotoxines for targeted PDT, as a synton for further chemical modification and as a promising PS has been widely recognized. There is a patented procedure at our disposal now allowing for preparation of a stable, well soluble and filtrating form of chlorine 6 - 'Photodithazine'. The elaborated production technology includes 4 steps. 'Photodithazine's 1-octanol/Phosphate buffer, pH 7.4 partition coefficient has been found to be 1.4, indicating that it must be able to localize in the plasma membrane. This may be a partial explanation of its higher photodynamic efficacy in vitro, comparing to 'Photosense' and its closeness to 'Photogem'.