Anticancer Activity of Copper (II) Complexes with a Pyridoxal-Semicarbazone Ligand

Three newly synthesized copper complexes: (Cu(PLSC)Cl2)(1), (Cu(PLSC)(H2O)(SO4))2.3H2O(2), (Cu2(PLSC)2(NCS)2) (NCS)2 (3) with pyridoxal semicarbazone (PLSC), as ligand, after being subjected to biological tests, showed anticancer activity. As ligand PLSC is biologically active, the results of biological activity are as expected. Specifically, an activity was demonstrated in breast cancer cells (MCF7 and MDA MB 231) and proliferative cells (MCF7). The results suggest that compound 1 exhibit no antiproliferative effect. Compound 2 exhibits cytotoxic effects on both cell lines, but only after 72 h treatment by the highest tested concentrations. Similar cytotoxicity pattern was observed for compound 3.