Cyclic amine sulfonamides as linkers in the design and synthesis of novel human β3 adrenergic receptor agonists

Abstract Piperidine, pyrrolidine, and azetidine sulfonamides were examined as linkers in designing novel human β 3 adrenergic receptor (β 3 -AR) agonists. The azetidine derivative 37 , and piperidine derivatives 7 , 8 , and 13 were found to be potent β 3 -AR agonists and have good selectivity against β 1 - and β 2 -AR.