Synthesis, absorption, emission and solvatochromic investigation of bioactive isatin tethered acridinedione conjugates

Abstract Fluorescent 1,8-acridiendione and pharmaceutically active isatin derivatives, connected via 1H-1,2,3-triazole bridge, has been designed by in silico molecular modeling and synthesized as a model compound to study of solvatochromism, photophysical analysis and biological studies. Solvatochromic study of the synthesized compound has been studied with wide range of polar and nonpolar solvents including water. Emission of the compound 1H-1,2,3-triazole tethered acridinedione-isatin (IAH) has also been studied by fluorescence spectroscopy. Further, these compounds have been subjected to antimicrobial efficacy towards microbial pathogens that are believed to cause varied nosocomial infections. We observed effective MIC values for the synthesized hybrid molecule against selected bacterial pathogens particularly, E. coli, P. vulgaris exhibited MIC values of 7.80, and 15.0 μg/mL respectively. In silico docking simulations of synthesized molecule IAH displayed the most efficient binding interactions with outer membrane permeability protein OprD. Also, the promising biological activity and computational ADME study indicates that the molecule IAH is significant and efficient for their potential as therapeutic drugs.