Regulation of Protein Kinase C

Distinct mechanisms operate to regulate the protein kinase C (PKC) gene family through the production of diacylglycerol (DAG). For the phospholipases C that act upon inositol lipids, agonist induced activation via disparate receptor types involves different strategies. This is likely to pertain to other sources of DAG. The production of DAG by these various means activates PKC isotypes in a non-uniform manner. This indicates that the context of DAG production is critical; whether this reflects coincident effectors (e.g. Ca2+, fatty acids) or compartmentalisation, has yet to be resolved.