Evaluation of Crystallization Behavior on the Surface of Nifedipine Solid Dispersion Powder Using Inverse Gas Chromatography

Hideo Miyanishi,Takayuki Nemoto,Masayasu Mizuno,Hisashi Mimura,Satoshi Kitamura,Yasunori Iwao,Shuji Noguchi,Shigeru Itai

Evaluation of Crystallization Behavior on the Surface of Nifedipine Solid Dispersion Powder Using Inverse Gas Chromatography

2013

Hideo Miyanishi
Takayuki Nemoto
Masayasu Mizuno
Hisashi Mimura
Satoshi Kitamura
Yasunori Iwao
Shuji Noguchi
Shigeru Itai

Purpose To investigate crystallization behavior on the surface of amorphous solid dispersion powder using inverse gas chromatography (IGC) and to predict the physical stability at temperatures below the glass transition temperature (T g).

Keywords:

Amorphous solid
Crystallization
Dispersion (optics)
Glass transition
Chromatography
Inverse gas chromatography
Chemistry
physical stability
pharmacology toxicology

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