Metastasis Suppressor NME1 Directly Activates Transcription of the ALDOC Gene in Melanoma Cells

Background/Aim: NME/NM23 nucleoside dipho-sphate kinase 1 (NME1) is a metastasis suppressor gene, exhibiting reduced expression in metastatic cancers and the ability to suppress metastatic activity of cancer cells. We previously identified NME1-regulated genes with prognostic value in human melanoma. This study was conducted in melanoma cell lines aiming to elucidate the mechanism through which NME regulates one of these genes, aldolase C (ALDOC).