Selection of gas chromatographic stationary phase pairs for characterization of the 1-octanol-water partition coefficient

Abstract Stationary phase pairs are recommended for the gas chromatographic estimation of log K values for the partition of organic compounds in 1-octanol—water. These pairs model the solute—solvent interactions in 1-octanol and water. The applicability of EPON 1001 as a polar and OV-1 as a non-polar phase was tested experimentally by measuring the retention indices of eight compounds with known log K values. The standard error in the log K determination was less than ± 0.16. The suggested method seems to be appropriate for the estimation of log K values without resorting to a large reference series.