The effect of Portulace oleracea polysaccharide on the blood endotoxin content and bacterial translocation in the liver of mice with intestinal microbial flora dysbiosis

Objective To explore the effect of Portulace oleracea polysaccharide(POP) on the blood endotoxin content as well as the bacterial translocation in the liver of mice with intestinal microbial flora dysbiosis.Method Lincomycin hydrochloride intragastric administration was used to establish intestinal micoflora dysbiosis in the mice,then POP was used to treat the mice,at this time the mice were put into either a standard control group,negative control group or positive control group.The mice were treated with POP for seven days when tests for blood endotoxin content as well as liver bacterial translocation were taken. Result After 3 days of Lincomycin hydrochloride intragastric administration,intestinal microbial flora dysbiosis was induced,blood endotoxin content increased,bacterial translocation of the liver begun.After 7 days of POP treatment the blood endotoxin content decreased,the amount of enterobacteria in the liver also decreased.Conclusion POP has a noticable positive effect on the endotoxin blood content,as well as bacterial translocation in the liver of mice with intestinal microbial flora dysbiosis.