Simultaneous blockade of 5-HT1A/B receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs: in vivo characterization of the novel 5-HT1A/B receptor antagonist/5-HT transport inhibitor SB-649915-B.

Zoe A. Hughes,Kathryn R. Starr,Claire M. Scott,Michael J. Newson,Trevor Sharp,Jeannette M. Watson,Jim J. Hagan,Lee A. Dawson

Simultaneous blockade of 5-HT1A/B receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs: in vivo characterization of the novel 5-HT1A/B receptor antagonist/5-HT transport inhibitor SB-649915-B.

2007

Zoe A. Hughes
Kathryn R. Starr
Claire M. Scott
Michael J. Newson
Trevor Sharp
Jeannette M. Watson
Jim J. Hagan
Lee A. Dawson

Rationale The delay in onset and treatment resistance of subpopulations of depressed patients to conventional serotonin reuptake inhibitors has lead to new drug development strategies to produce agents with improved antidepressant efficacy.

Keywords:

Endocrinology
Receptor antagonist
Transport inhibitor
Internal medicine
Anesthesia
5-HT receptor
Antidepressant
Serotonin
Pharmacology
Serotonin reuptake inhibitor
5-HT1A receptor
Biology
Receptor
Reuptake inhibitor
Neurotransmitter
Antagonist

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