Establishment of Hamster Model for Taenia solium

【Objective】 To carry out the observation of pathogen, biologic characteristics of Taenia solium and solve the problem of material source for Taenia solium, experimental model of Taenia solium in hamsters was established. 【Method】 The immune-suppressed hamster was infected orally with Cysticercus cellulosa in order to observe the biological characteristics of Taenia solium in hamsters such as infectivity, growth and development and parasitic site, and the morphological structure of detected cestode in hamsters was obersved using the squash technique and tissue section technique. 【Result】 At the 5mg dose of the immunosuppressant, the hamster was infected only one time, and Cysticercus cellulosa could grow to adult. At the same time, the detectable rate of Taenia solium was very high, the cestode containing somite could be detected in the hamste, after 80d infection, gravid proglottid could be detected. The most polypide adsorbed in ahead of 1/3 small intestine, some were also found in gall bladder and bile duct, even some escaped form gall bladder and parasited in liver. Four suckers and two cycles of granular structure were found in scolex. Compared with human-taenia solium, mature proglottids were fewer. 【Conclusion】 The experimental model of Taenia solium in hamsters has been successfully developed in this experiment. This made it becomes possible to successfully solve the problem of material source for Taenia solium, and has also laid a foundation for the further research of Taenia solium.