Receptor antagonists azaindane piperidinone carboxamide CGRP

A compound of Formula I: Formula ** ** or a pharmaceutically acceptable salt thereof, for use in the acute or prophylactic treatment of migraine headache or cluster headache in conjunction with one or more agents selected from: an anti-migraine agent; an agonist of 5-HT1B / 1D; an agonist of 5-HT1D; an agonist of 5-HT1F; cyclooxygenase inhibitor; an anti-inflammatory agent or non-steroidal anti-inflammatory suppressive cytokine agent; a glucocorticoid and an analgesic; wherein: X is selected from -C (R8)> = or -N> =, where R8 is hydrogen, F or CN; R1 is selected from the group consisting of: C1-4 alkyl, cyclopropylmethyl, cyclobutylmethyl and [1- (trifluoromethyl) cyclopropyl] methyl, each of which is optionally substituted with one or more substituents as allowed by valence selected independently selected from the group consisting of: F and hydroxyl; R2 is selected from hydrogen and methyl; when R2 is hydrogen then R3 is selected from hydrogen, F or Cl; R4 is selected from hydrogen, F or Cl; R5 is hydrogen; R6 is selected from hydrogen or F; and R7 is selected from hydrogen, F or Cl; except that at least two of R3, R4, R6 and R7 must be F or Cl, unless R3 is F in which case R4, R6 and R7 may be all hydrogen; and if R4 is Cl then R7 can not be Cl; when R2 is methyl then R3 is selected from hydrogen, methyl, F, Cl or Br; R4 is selected from hydrogen, methyl, F or Cl; R5 is selected from hydrogen or F; R6 is selected from hydrogen or F; and R7 is selected from hydrogen, methyl, F or Cl; except that if R5 is F then at least three of R3, R4, R6 and R7 must be F; and if R4 is methyl or Cl then R7 can not be methyl or Cl.