Influence on mitochondria ultrastructure of right ventricle during intermittent hypoxia and swimming exercise in rats

Objective:To observe the mitochondria ultrastructure of right ventricle during intermittent hypoxia and swimming exercise in rats to offer experimental data in plateau iatrical research.Method:Wistar rats were randomly divided into the normoxia control group,the hypoxia control group and the hypoxia training group.Blood pressure and heart rate were recorded by MPA-heart function analytical system.Mitochondria ultrastructure of right ventricle was observed by transmission electron microscope.Result:The hypoxia control group:Mitochondria hyperplasia,extruded deformation,mitochondrial crista and matrix increasing obviously and a great quantity vacuoles among mitochondria were found.Disarrangement and agglutinative deformation of mitochondria were also observed.The hypoxia training group:Mitochondria increasing under sarcolemma and arranging regularly were found.Mitochondrial matrix increasing could be observed under high power lens.Conclusion:The mitochondria ultrastructure of right ventricle was damaged during hypoxia,and the mitochondria ultrastructure of right ventricle improved significantly during intermittent hypoxia and swimming exercise.