A mouse knockout library for secreted and transmembrane proteins

Tracy Tang,Li Li,Jerry Tang,Yun Li,Wei Yu Lin,Flavius Martin,Deanna Grant,Mark Solloway,Leon Parker,Weilan Ye,William F. Forrest,Nico Ghilardi,Tamas Oravecz,Kenneth A. Platt,Dennis S. Rice,Gwenn M. Hansen,Alejandro Abuin,Derek E. Eberhart,Paul J. Godowski,Kathleen H. Holt,Andrew S. Peterson,Brian Zambrowicz,Frederic J. de Sauvage

A mouse knockout library for secreted and transmembrane proteins

2010

Tang et al. present the first large-scale, gene-specific library of knockout mice. They disrupt 472 genes encoding secreted or transmembrane proteins and report the results of a comprehensive phenotypic analysis.

Keywords:

Homologous recombination
Transmembrane protein
Membrane protein
Molecular biology
Secretory protein
Knockout mouse
Phenotype
Mutation
Gene
Biology
phenotypic analysis
Ratón

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