Effect of CYP2C9 Polymorphisms on the Pharmacokinetics of Indomethacin During Pregnancy

Mansi K. Shah,Meixiang Xu,Poonam Shah,Xiaoming Wang,Shannon Clark,Maged Costantine,Holly West,Tatiana Nanovskaya,Mahmoud S. Ahmed,Sherif Z. Abdel-Rahman,Raman Venkataramanan,Steve N. Caritis,Gary D.V. Hankins,Erik Rytting

Effect of CYP2C9 Polymorphisms on the Pharmacokinetics of Indomethacin During Pregnancy

2019

Mansi K. Shah
Meixiang Xu
Poonam Shah
Xiaoming Wang
Shannon Clark
Maged Costantine
Holly West
Tatiana Nanovskaya
Mahmoud S. Ahmed
Sherif Z. Abdel-Rahman
Raman Venkataramanan
Steve N. Caritis
Gary D.V. Hankins
Erik Rytting

Background and Objective Cytochrome P450 (CYP) 2C9 catalyzes the biotransformation of indomethacin to its inactive metabolite O-desmethylindomethacin (DMI). The aim of this work was to determine the effect of CYP2C9 polymorphisms on indomethacin metabolism in pregnant women.

Keywords:

CYP2C9
Biochemistry
Biotransformation
Metabolism
Cytochrome P450
Chemistry
Metabolite
Pregnancy
Pharmacokinetics
Clinical chemistry
Anesthesia
Genotype
Tocolytic agent
Pharmacology
Buccal swab

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