DEPLETION ZONE ISOTACHOPHORESIS (dzITP): BEATING THE SIMPLICITY OF ELECTROPHORESIS

A radically novel approach towards isotachophoresis is presented in which a nanochannel-induced ionic depletion zone replaces a trailing electrolyte. This makes depletion zone isotachophoresis (dzITP) a single-electrolyte focusing and separation technique. Moreover, focusing strength and positions of analyte zones can be precisely controlled by a three-point voltage actuation scheme. Thus, dzITP provides unprecedented versatility and simplicity.