In vitro activity of doripenem against Acinetobacter baumannii clinical isolates

Abstract Doripenem is a carbapenem with activity against Gram-positive and Gram-negative pathogens. This study evaluated the in vitro activity of doripenem against a collection of 87 Acinetobacter baumannii clinical isolates, showing that the activity of doripenem was superior to imipenem and meropenem for strains carrying the bla OXA-58 gene. A. baumannii clinical isolates expressing the bla OXA-24 gene were resistant to doripenem, imipenem and meropenem. However, in clinical isolates expressing the bla OXA-58 gene, the percentage of isolates with a doripenem minimum inhibitory concentration >8 μg/mL was much lower than that of imipenem and meropenem. This study shows that the activity of doripenem was superior to imipenem and meropenem for strains carrying the bla OXA-58 gene.