Myeloperoxidase Inactivation Affects Neutrophil Recruitment in ZebrafishInjury-Induced Model
2017
Uncontrolled migration and excess recruitment of neutrophils can lead to persistent inflammation, tissue damage
and disease. Myeloperoxidase is a remarkable target for further understanding the immune cell migration. This study
tests the hypothesis that myeloperoxidase may regulate the immune cell activity and provides a new perspective on
the treatment of immune diseases by exploring the mechanism of neutrophil migration. Studies of leukocyte
migration in vivo in the zebrafish model, which set a collection of advantages both mammalian and cell lines, have
gained widespread attention. In this study, we used tg (coro1a: eGFP; lyz: dsred2) and tg (lyz: eGFP) lines labelling
both macrophages and neutrophils to study the effect of mpx on neutrophil chemotaxis to wounds. We found that
myeloperoxidase was required for neutrophil migration to the wound site in injury-induced inflammation, but not
required for neutrophil migration to the infection site in the infection-induced inflammation. Further, the regulation of
myeloperoxidase was specific to neutrophil migration to wound inflammation, but was not necessary for macrophage
migration. Thus, myeloperoxidase activity shows therapeutic potential for inflammatory disease related to neutrophil
migration.
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