Dietary supplementation with grape seed extract prevents development of trigeminal sensitization and inhibits pain signaling in a preclinical chronic temporomandibular disorder model.

As reported by the National Institute of Dental and Craniofacial Research, temporomandibular disorders (TMD) are the most prevalent orofacial pain conditions for which patients seek treatment. TMD, a chronic disease that affects between 5-12% of the adult population, is characterized by pain in the muscles and temporomandibular joint (TMJ) associated with mastication.