Synthesis of Phosphodiesterase IVb Inhibitors. Part 2. Stereoselective Synthesis of Hexahydro-3H-pyrrolo[1,2-c]imidazol-3-one and Tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-one Derivatives.

Petr A. Zhmurov,Andrey A. Tabolin,A. Yu. Sukhorukov,Alexey V. Lesiv,M. S. Klenov,Yu. A. Khomutova,S. L. Ioffe,V. A. Tartakovsky

Synthesis of Phosphodiesterase IVb Inhibitors. Part 2. Stereoselective Synthesis of Hexahydro-3H-pyrrolo[1,2-c]imidazol-3-one and Tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-one Derivatives.

2012

Petr A. Zhmurov
Andrey A. Tabolin
A. Yu. Sukhorukov
Alexey V. Lesiv
M. S. Klenov
Yu. A. Khomutova
S. L. Ioffe
V. A. Tartakovsky

Starting from the known nitrone (I), the highly potent phosphodiesterase IVb inhibitors (VII) and (X) are stereoselectively synthesized in an overall yield of 22% and 18%, respectively.

Keywords:

Phosphodiesterase
Stereochemistry
Nitrone
Organic chemistry
Stereoselectivity
Chemistry

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