FORMULATION AND EVALUATION OF VORICONAZOLE FLOATING TABLETS

The present study involves in the preparation and evaluation of floating tablets of Voriconazole by wet granulation method by using the hydrophilic polymer such as hydroxy propyl methyl cellulose (HPMC K4M) and Carbopol 934 P. Sodium bicarbonate and citric acid were incorporated as gas generating agent. The study aims to achieve extended retention in the stomach which may result in prolonged absorption in proximal part of the small intestine. The prepared tablets were evaluated in terms of thickness, average weight, hardness, friability, drug content uniformity, swelling index, in- vitro buoyancy study and in-vitro dissolution study. The formulated tablet Hardness was found to being the range of 5.5 0.42 to 7.00.35 kg/cm2, the % friability was in the range of 0.72+ 0.26 to 0.96+ 0.14. In-vitro release studies were carried out using USP XXII dissolution test apparatus. The tablet containing Voriconazole was released from batch F1-F5 found to be 75.12 to 97.2 %. The release of drug from tablets sufficiently sustained for 12 hours by in vitro release study. The lower polymer to drug ratio there was a significant increase in drug release, F2 found to be the best formulation.