Thermodynamics of the Solvation of β-Cyclodextrin in Water–Dimethylsulfoxide Solvents

The Gibbs energy of transfer is determined via the interphase distribution of a substance between two immiscible phases. β-cyclodextrin (βCD) from water is used in a mixture with dimethylsulfoxide (χDMSO = 0.0–0.6 mole fraction) at 298 K. The effect of the solvent’s composition has on the thermodynamic characteristics of βCD solvation is analyzed. It is found that increasing the content of DMSO in a mixed solvent leaded to negligible desolvation of cyclodextrin, due probably to the compensation effect between the enthalpy and entropy components of the Gibbs energy of βCD transfer.