Role of Phospholamban (PLN), Triadin (TRDN), and Junctin (ASPH) Genes in the Development of Myocardial Contractile Dysfunction

The review covers studies evaluating the role of genes and proteins of phospholamban (PLN), triadin (TRDN), and junctin (ASPH) in the development of myocardial contractile dysfunction. The results reflecting the effect of changes in the structure and expression of these genes on the functioning of the Ca2+ transporting system of the sarcoplasmic reticulum of cardiomyocytes are presented.