Myosin dilated cardiomyopathy mutation S532P disrupts actomyosin interactions, leading to altered muscle kinetics, reduced locomotion, and cardiac dilation in Drosophila.

We explored the mechanism of human myosin–induced dilated cardiomyopathy (DCM) using the Drosophila melanogaster model system. We discovered that the S532P myosin DCM mutation reduces the actin-dep...