Synthesis and Biological Evaluation of Novel 6-Aryl-2,4-Disubstituted Schiff's Base 1,3,5-Triazine Derivatives as Antimicrobial Agents

Novel Schiff’s bases of 1,3,5-triazine derivatives were designed and synthesized from cyanuric chloride. The structures of all compounds have been confirmed by FT-IR, 1 H NMR and Mass spectral analysis. Biological activities of synthesized compounds were evaluated by using serial dilution method in dimethyl sulphoxide media against bacterial and fungal strain cultures by comparing with standard Streptomycin and Fluconazole drug. Results reveals that the synthesized novel triazine based Schiff’s bases are more potent than its DIPOD (Dialdehyde). The present work suggests that triazine based Schiff’s base derivatives may become a lead compound for anti-microbial drugs.