Tetrabutylammonium Pyridin-2-olate : A New Reagent for the Efficient Synthesis of N-Aryl Pyridin-2-ones
2008
A new reagent, tetrabutylammonium pyridin-2-olate, was prepared and its application to the efficient synthesis of N-aryl pyridine-2-ones was demonstrated using CuI-catalyzed coupling reactions with aryl iodides. This coupling reaction is mild, high-yielding, and remarkably chemoselective (N- vs. O-arylation). It is also compatible with substrates containing labile functional groups.
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