The effect of anagliptin treatment on glucose metabolism and lipid metabolism, and oxidative stress in fasting and postprandial states using a test meal in Japanese men with type 2 diabetes

Keywords Anagliptin Test meal Adiponectin Remnant Renal function 8-OHdGIt has been generally recognized that postprandial hyper-glycemia and hyperlipidemia are highly related to thedevelopment of atherosclerosis [1, 2]. Hyperglycemia isknown to damage vascular endothelial cells, increase oxi-dative stress, promote the expression of adhesion moleculeand inhibit nitric oxide (NO) production [3]. Remnantlipoprotein, an important component of postprandialhyperlipidemia, promotes foam cell formation of macro-phages and proliferation of smooth muscle cells [4].Dipeptidyl peptidase 4 (DPP-4) inhibitors have attractedattention as a new class of anti-diabetic agents for thetreatment of type 2 diabetes [5]. Anagliptin, a member ofthe medication class of DPP-4 inhibitors, has been recentlyavailable in the market in Japan. Animal studies suggestthat anagliptin treatment is associated with improvement ofglucose tolerance either by amelioration of insulin resis-tance or enhancing insulin secretion [6] and the decrease inthe development of atherosclerosis [7]. However, to ourknowledge, there has been no clinical study. In this back-ground, we investigated the effect of anagliptin treatmenton glucose and lipoprotein metabolism in fasting andpostprandial state using a test meal (JANEF E460F18 ,Q.P. Co., Tokyo, Japan).Ten Japanese men with type 2 diabetes (age66.3 ±9.5 years; body mass index (BMI) 26.6 2.2 kg/m