Novel nucleotide triphosphates as potent P2Y2 agonists with enhanced stability over UTP.

Abstract The synthesis of a series of novel C-linked nucleotide triphosphates is reported. These exhibit excellent agonist potency and selectivity for the P2Y 2 receptor with a number of examples having EC 50 values below 10 nM. Representative compounds from the N-linked and C-linked series showed enhanced metabolic stability compared with that of the natural ligand UTP.