A simple method for the protection of aryl amines as their t-butylcarbamoyl (Boc) derivatives

Abstract It has been found that aryl amines can be directly protected as their Boc derivatives by treatment of the amine with two equivalents of NaHMDS in THF followed by one equivalent of di- t -butyldicarbonate. This procedure works on a wide variety of both electron-rich and electron-deficient aryl amines.