Chronic prolonged hyponatremia and risk of hip fracture in elderly patients with chronic kidney disease

Abstract Background Chronic prolonged hyponatremia (CPH) is a risk factor for hip fracture in the general population. Whether CPH increases hip fracture risk in chronic kidney disease (CKD) patients is unknown. Methods Case-control study in patients over 60 years of age with stage 3 or greater CKD. Patients who had a hip fracture were referred to as cases (n = 1236) and controls had no hip fracture (n = 4515). Patients were classified as having CPH if serum sodium was 70 years versus ≤70 years. Results CPH was present in 21% of cases and 10% of controls (p  Conclusion Chronic prolonged hyponatremia is a risk factor for hip fracture in CKD patients older than 60 years of age.