Reactive oxygen species and NADPH oxidase 4 induced by transforming growth factor β1 are the therapeutic targets of polyenylphosphatidylcholine in the suppression of human hepatic stellate cell activation

Remina Ikeda,Kyoko Ishii,Yoshiko Hoshikawa,Junya Azumi,Yuta Arakaki,Toshihiro Yasui,Shizuka Matsuura,Yoshiaki Matsumi,Yohei Kono,Yusuke Mizuta,Akihiro Kurimasa,Ichiro Hisatome,Scott L. Friedman,Hironaka Kawasaki,Goshi Shiota

Reactive oxygen species and NADPH oxidase 4 induced by transforming growth factor β1 are the therapeutic targets of polyenylphosphatidylcholine in the suppression of human hepatic stellate cell activation

2011

Remina Ikeda
Kyoko Ishii
Yoshiko Hoshikawa
Junya Azumi
Yuta Arakaki
Toshihiro Yasui
Shizuka Matsuura
Yoshiaki Matsumi
Yohei Kono
Yusuke Mizuta
Akihiro Kurimasa
Ichiro Hisatome
Scott L. Friedman
Hironaka Kawasaki
Goshi Shiota

Objective and design To clarify the molecular mechanism of polyenylphosphatidylcholine (PPC), we examined the involvement of reactive oxygen species (ROS) and NADPH oxidase 4 (Nox4) in human hepatic stellate cells (HSCs).

Keywords:

Biology
Cell growth
Biochemistry
Hepatic stellate cell
Hepatic stellate cell activation
NOX4
Oxidative stress
Transforming growth factor
NADPH oxidase
Reactive oxygen species
Cell biology
molecular mechanism

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