Stereoselective synthesis of dendrobate alkaloid (+)-241D and its C-4 epimer
2010
Abstract An efficient stereoselective synthesis of dendrobate alkaloid (+)-241D and its C-4 epimer was achieved from the inexpensive, commercially available starting material decanal ( 10 ) in an overall yield of 21.9% and 21.1%, respectively. This synthesis utilizes the key steps of Maruoka asymmetric allylation, one-pot epoxidation followed by nucleophilic addition of an organomagnesium reagent (Forsyth’s protocol) and subsequent functional group transformations.
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