Structural Determination of NSC 670224, Synthesis of Analogues and Biological Evaluation

In the search for new lead compounds for drug discovery, small molecule and natural product libraries of known biologically active compounds are being investigated by high-throughput (HT) screening methods for potential new uses. One such screening protocol employs the budding yeast Saccharomyces cerevisiae as a platform that is both convenient and broadly applicable. Yeast and mammalian cells have many conserved cellular processes, yeast deletion mutants are widely available and profiling samples across the genome-wide yeast deletion libraries can facilitate target identification.[1-3]