Synthesis and Anti-Inflammatory Activity of Some New Pyrimidinothienocinnoline Derivatives

Synthesis of a new series of pyrimidinothienocinnoline derivatives involves the reaction of 9-aminodibenzo[f, h]pyrimido[4′,5′:4,5]thieno[2,3-c]cinnoline-8-carbonitrile with formamide that gives 8-amino-dibenzo[f, h]-pyrimido[4′,5′:4,5]thieno[2,3-c]cinnoline. Reactions of the latter with morpholine, piperidine, malononitrile, phenylbromide, aromatic aldehydes, and ethyl cyanoacetate have been studied. Some synthesized compounds have been subjected to further transformations. The synthesized pyrimidinothienocinnoline derivatives are tested for their anti-inflammatory activity.