Study on the Nano-scaled Molecules Used in Treatment for Melanoma Using Bio-chemical and Computational Analysis

When the production of Reactive Oxygen Species exceeds the capacity for anti-oxidation, the result is cell damage or cell death in melanoma caused by toxicity. This paper conducts a study on the chemo-preventive agents and the resulting chemoprevention. For example, plant polyphenols are examined for their potential to inhibit the process of reactive chain reactions in the UV-exposed skin. In addition, the paper analyzes the chemical and physical properties of the polyphenols that may be useful for skin diseases associated with solar UV radiation-induced inflammation and oxidative stress. Using computational programs, various information about molecules of polyphenols with functional groups is extracted. The optimization energies (kJ/mol) of the molecules are computed and used to determine the characteristics and stability of the molecules. Dipole moments (D) are used to determine the reactivity of the molecules. Measurement of the molecules' stability and reactivity allows evaluation of polyphenols and their ability to inhibit reactive chain reactions caused by Reactive Oxygen Species.