Effects of cariprazine on extracellular levels of glutamate, GABA, dopamine, noradrenaline and serotonin in the medial prefrontal cortex in the rat phencyclidine model of schizophrenia studied by microdialysis and simultaneous recordings of locomotor activity

Jan Kehr,Takashi Yoshitake,Fumio Ichinose,Shimako Yoshitake,Béla Kiss,Istvan Gyertyan,Nika Adham

Effects of cariprazine on extracellular levels of glutamate, GABA, dopamine, noradrenaline and serotonin in the medial prefrontal cortex in the rat phencyclidine model of schizophrenia studied by microdialysis and simultaneous recordings of locomotor activity

2018

Jan Kehr
Takashi Yoshitake
Fumio Ichinose
Shimako Yoshitake
Béla Kiss
Istvan Gyertyan
Nika Adham

Rationale Aberrant glutamatergic, dopaminergic, and GABAergic neurotransmission has been implicated in schizophrenia. Cariprazine reverses the behavioral effects observed in the rat phencyclidine (PCP)-induced model of schizophrenia; however, little is known about its in vivo neurochemistry.

Keywords:

Endocrinology
Internal medicine
Cariprazine
GABAergic
Dopamine
Prefrontal cortex
Glutamate receptor
Psychology
Phencyclidine
Neurochemistry
Dopaminergic
Serotonin
Aripiprazole
Microdialysis

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