Targeting stem cell niche can protect hematopoietic stem cells from chemotherapy and G-CSF treatment.
2015
Introduction
Hematopoietic stem/progenitor cells (HSPCs) reside in a tightly controlled local microenvironment called bone marrow niche. The specialized microenvironment or niche not only provides a favorable habitat for HSPC maintenance and development but also governs stem cell function.
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