Renal Iron Metabolism: Transferrin Iron Delivery and the Role of Iron Regulatory Proteins

In mammalian cells, iron is required for the function of many prosthetic groups, including heme and iron-sulfur clusters. Mammals absorb dietary iron and heme across the apical mucosa of duodenal epithelial cells using a Fe2+ transporter known as divalent metal transporter 1 (DMT-1; also known as