A New Perspective for Osteosarcoma Therapy: Proteasome Inhibition by MLN9708/2238 Successfully Induces Apoptosis and Cell Cycle Arrest and Attenuates the Invasion Ability of Osteosarcoma Cells in Vitro

Renhao Liu,Chunjiang Fu,Jiabing Sun,Xvming Wang,Shuo Geng,Xiaoyu Wang,Jilong Zou,Zhenggang Bi,Chenglin Yang

A New Perspective for Osteosarcoma Therapy: Proteasome Inhibition by MLN9708/2238 Successfully Induces Apoptosis and Cell Cycle Arrest and Attenuates the Invasion Ability of Osteosarcoma Cells in Vitro

2017

Renhao Liu
Chunjiang Fu
Jiabing Sun
Xvming Wang
Shuo Geng
Xiaoyu Wang
Jilong Zou
Zhenggang Bi
Chenglin Yang

Background: The proteasome exists in all eukaryotic cells and provides the main route of intracellular proteins degradation involved in cell growth and apoptosis.

Keywords:

Biochemistry
Cell biology
Apoptosis
Intracellular
Osteosarcoma
Proteasome inhibitor
Biology
Cell growth
Cell cycle checkpoint
Mitochondrion
Proteasome
E2F1 Transcription Factor
Cancer research
Bcl-2-associated X protein

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations