Role of hepatocytic Xbp1 in a preclinical model of toxic liver injury

Drug-induced liver injury (DILI) is a leading cause of acute liver injury, including acetaminophen (APAP) overdose. Endoplasmic reticulum (ER) stress is an unexplored but very likely a triggering mechanism of APAP-induced liver injury. Under stress conditions, ER can initiate the unfolded protein response (UPR). However, the mechanisms of ER stress and UPR remain poorly understood. In this study, we overall aimed to unveil the relevance of the IRE1α-XBP1 arm, the most highly conserved arm of UPR, during APAP-induced acute liver failure (ALF) and provide the basis for therapeutic intervention...