Experimental investigation of residence time, granulation liquid and granule size distributions in twin-screw granulation

a. BIOMATH, Dept. of Mathematical Modelling, Statistics and Bioinformatics, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B9000 Gent, Belgium b. Laboratory of Pharmaceutical Process Analytical Technology, Dept. of Pharmaceutical Analysis, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium c. School of Pharmacy, University of Eastern Finland, Kuopio, Finland d. Laboratory of Pharmaceutical Technology, Dept. of Pharmaceutics, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium e. Optical Measurement Technologies, VTT Technical Research Centre, Kuopio, Finland f. CAPEC-PROCESS, Department of Chemical and Biochemical Engineering, Technical University of Denmark, 2800 Kongens Lyngby, Denmark