TITLE: STUDY OF HISTOPATHOLOGICAL EFFECTS OF ARSENIC ON KIDNEYS OF ALBINO RATS. 1 Bonita Gupte , 2 Sangeeta Gupta, 3Vanita Gupta, 4Bhawna Sharma, 5Vikrant Singh . 6 Kour Rishu

Context: Arsenic is a common pollutant of water in developing counties and leads to major health problems and clinical conditions. It affects all organs of the body and can be lethal in higher doses. Aims: To study the histopathological effects of arsenic on kidney of albino rat and compare it with rats that are not exposed. Methods and Material: 18 rats, each divided in the group of 3, having 6 rats each. Group A acted as control group and, Group B and Group C, acted as test group which received Sodium Arsenite, in drinking water. Kidney tissue was sectioned, stained and examined under Light microscope. Results: The kidneys of rats exposed to low dose of arsenic showed decrease in the size of the glomerulus, increased periglomerular space with mild congestion of vessels and haemorrhage. Those exposed to high dose of arsenic, revealed a disrupted architecture, loss of brush border in cells of PCT, vacuolation and cloudy swelling, cell sloughing and desquamation. Large areas of haemorrhagic foci and mononuclear infiltrate were spotted. Conclusions: We conclude from the present work that experimental administration of Arsenic to rats was associated with histological changes in the form of renal toxicity in the test groups. Key-words: Histo-pathology, Kidney, rat, Sodium Arsenite