Synthesis of new nicotinic acid hydrazide metal complexes: potential anti-cancer drug, supramolecular architecture, antibacterial studies and catalytic properties.

Abstract In this study, Eight new transition metal complexes (Co(II), Ni(II), Cu(II), and Zn(II)) were obtained via condensation with thiophene-appended nicotinic acid hydrazide ligands (L5 and L6), synthesized and characterized structurally by spectroscopically and thermogravimetrically. We study the catalytic properties by multi-component Biginelli reaction with catalytic amount of our transition metal complexesin the presence of solvent. While increasing the catalyst concentration from 1.414 × 10−2mmol into 8.486 × 10−2 mmol there is no appreciable change. In vitro anti-cancer activity of L5 & L6 and their metal complexes was done on human colorectal cancer HT29 cell line, the synthesized metal complexes showed higher anti-proliferative activity at lower concentrations compared to the free ligands alone. The synthesized molecules can be extended into 2D and 3D supramolecular networking through π-π stacking, H-bonding and hydrophobic contactsbythe receptor thymidylate synthase. Antibacterial activity of synthesized Co(II) and Zn(II) complexes showed significant inhibition on the growth of both gram positive and gram negative bacteria compare to the free L5 and L6 ligands.These results were display that thiophene-appended nicotinic acid hydrazidederivatives, in particularlycomplexes L5–Zn(II) and L5-Co(II), might be used for the design of new antineoplastic agents.