Morphological active contour model for automatic brain tumor extraction from multimodal magnetic resonance images.

Abstract Background Brain tumor extraction from magnetic resonance (MR) images is challenging due to variations in the location, shape, size and intensity of tumors. Manual delineation of brain tumors from MR images is time-consuming and prone to human errors. Method In this paper, we present a method for automatic tumor extraction from multimodal MR images. Brain tumors are first detected using k-means clustering. A morphological region-based active contour model is then used for tumor extraction using an initial contour defined based on the boundary of the detected brain tumor regions. The contour evolution for tumor extraction was performed using successive application of morphological operators. In our model, a Gaussian distribution was used to model local image intensities. The spatial correlation between neighboring voxels was also modeled using Markov random field. Results The proposed method was evaluated on BraTS 2013 dataset including patients with high-grade and low-grade tumors. In comparison with other active contour based methods, the proposed method yielded better performance on tumor segmentation with mean Dice similarity coefficients of 0.9179 ( ± 0.025) and 0.8910 ( ± 0.042) obtained on high-grade and low-grade tumors, respectively. Conclusion The proposed method achieved higher accuracies for brain tumor extraction in comparison to other contour-based methods.