Benzylgermanium Compounds as Modifiers of Silica Gel Surface During a Chromatographic Process

In the paper are presented results of investigations concerning modification of silica gel by mono-, di-, and tribenzylgermanium during a chromatographic process. These compounds exhibit biological activity and are characterized by low toxicity. Germanium compounds are widely applied in oncological therapy. The investigations unambiguously show that the above mentioned derivatives can modify silica gel surface. These results have been confirmed by FTIR, 13 C CP/MAS NMR, 29 Si CP/MAS NMR and scanning microscopy. The strongest bonds are formed by monobenzyl derivative, slightly weaker bonds are formed by dibenzyl and the weakest bonds (because of sterically large group) formed by tribenzyl derivative. The mass ratio of germanium to silica after modification was monobenzyl derivative, for 15.02%, 11.05%, for dibenzyl and 7.10% for tribenzyl.