MicroRNA-18a Attenuates DNA Damage Repair through Suppressing the Expression of Ataxia Telangiectasia Mutated in Colorectal Cancer

Chung-Wah Wu,Yujuan Dong,Qiaoyi Liang,Xinqi He,Simon S.M. Ng,Francis K.L. Chan,Joseph J.Y. Sung,Jun Yu

MicroRNA-18a Attenuates DNA Damage Repair through Suppressing the Expression of Ataxia Telangiectasia Mutated in Colorectal Cancer

2013

Chung-Wah Wu
Yujuan Dong
Qiaoyi Liang
Xinqi He
Simon S.M. Ng
Francis K.L. Chan
Joseph J.Y. Sung
Jun Yu

Background miR-18a is one of the most up-regulated miRNAs in colorectal cancers (CRC) based on miRNA profiling. In this study, we examined the functional significance of miR-18a in CRC.

Keywords:

Three prime untranslated region
Ataxia-telangiectasia
Etoposide
microRNA
Cancer research
DNA damage
Colorectal cancer
RNA interference
Apoptosis
Biology
Bioinformatics
DNA repair

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