A Facile Route to 5-Methyl-5H-indeno[1,2-c]quinolones via Palladium-Catalyzed Cyclization of 2-Alkynylbromobenzenes with N,N-Dimethyl-2-alkynylanilines.

A tandem reaction catalyzed by palladium is developed to provide a facile and simple route for the synthesis of 5-methyl-5H-indeno[1,2-c]quinolones, which can introduce diversity and complexity into the products from readily available starting materials. This transformation proceeds well with good functional group tolerance.