北平顶猴(Macaca leonina)血液学和血液生化指标参考值的测定与分析
2013
The pig-tailed macaque is an important non-human primate experimental
animal model that has been widely used in the research of AIDS and
other diseases. Pig-tailed macaques include Mentawai macaques ( Macaca
pagensis ), Sunda pig-tailed macaques( M. nemestrina ) and northern
pig-tailed macaques (M. leonina). Northern pig-tailed macaques inhabit
China and surrounding Southeast Asia countries. To our knowledge, no
reports have been published regarding the hematology and blood
chemistry parameters of northern pig-tailed macaques, which are
important for the objective evaluation of experimental results. We
measured and analyzed 18 hematology parameters and 13 blood chemistry
parameters in juvenile (aged 2−4 years) and adult (aged
5−10 years)northern pig-tailed macaques. We found that red blood
cells, hemoglobin and alkaline phosphatase values were lower in female
macaques than male macaques in both juvenile and adult groups. White
blood cells, lymphocyte, monocytes, platelet distribution width,
cholesterol, aspartate aminotransferase and alkaline phosphatase values
were higher in juvenile macaques than adult macaques, while creatinine
and triglycerides values were lower in juvenile macaques. Mean
corpuscular hemoglobin and creatinine values werepositively correlated
with weight in juvenile groups. In adult groups, mean corpuscular
hemoglobin, percentage of granulocyte, hemoglobin and creatinine were
also positively correlated with weight, and lymphocyte, percentage of
lymphocyte, red cell distribution width, aspartate aminotransferase and
cholesterol values were negatively correlated with weight. The results
suggest that age, gender and weight of northern pig-tailed macaques
affected their hematology and blood chemistry parameters. This
hematological and blood chemistry study has great significance in
biomedical research and animal models using northern pig-tailed macaque
as an experimental animal.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
0
References
8
Citations
NaN
KQI