Synthesis, crystal structures, and antitumor activity of three new organotin carboxylates

Three new organotin(IV) carboxylates of composition [(R)2Sn(O2CC6H4C-OC6H4CH3)2] 1, [(R)2Sn(O2CC6H4COC6H4-C2H5)2]22, and R3SnO2 CC6H4COC6H4CH33, were obtained by reactions of (R)2SnO [R = o-tolyl] with 2-(4-methyl benzoyl) benzoic acid and 2-(4-ethyl benzoyl) benzoic acid, and reaction of Cy3SnOH [Cy = cyclohexyl] with 2-(4-methyl benzoyl) benzoic acid, respectively. The complexes 1, 2 and 3 have been characterized by elemental analysis, infrared (IR), 1HNMR, and X-ray crystallography diffraction analyses. The complex 1 has two folded symmetrical structure; the tin atom in 1 is found to adopt a distorted toward skew-trapezoidal bipyramidal geometry. Molecular structure of the complex 2 is centrosymmetric, and the internal tin atom is five-coordinated and is in distorted trigonal bipyramidal geometry. The crystal structure of the complex 3 is found to exhibit distorted tetrahedral geometry. Pilot studies have indicated that the complexes 1 and 2 have shown good antitumor activities. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:304–313, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20614