Hyperbranched polyester poly(3-diethylaminepropionate)s and their copper(II) complexes: Synthesis, characterization and biological investigation

Abstract New polydentate ligands based on hyperbranched second and third generation polyesters containing terminal (3-diethylamino)propionate fragments and their polynuclear copper(II) complexes were synthesized and characterized by spectroscopic methods. The acid-base properties spectroscopy determined that the functionalization degree of the diethylamine-modified hyperbranched polyesters ( L I , L II ) increases from the second (56%) to third (81%) generation. The polynuclear complexes Cu(II)– L I and Cu(II)– L II were observed. A coordination site of the complexes contains paramagnetic fragment CuN 2 O 2 Solv 2 where Solv is H 2 O or DMSO. The hyperbranched poly(ester amine) of the third generation have strong antifungal activity against Aspergillus fumigatus culture, and its metal complex is active against Candida albicans culture.